high quality 99.5-100.5% tech food grade Fumaric acid

< Span >high quality 99.5-100.5% tech food grade Fumaric Acid

Fumaric acid or trans-butenedioic acid is the chemical compound with the formula HO2CCH=CHCO2H. It is produced in eukaryotic organisms from succinate in complex 2 of the electron transport chain via the enzyme succinate dehydrogenase. It is one of two isomeric unsaturated dicarboxylic Acids, the other being maleic acid. In fumaric acid the carboxylic acid groups are trans (E) and in maleic acid they are cis (Z). Fumaric acid has a fruit-like taste.
The salts and esters are known as fumarates. Fumarate can also refer to the C4H2O2−4 ion (in solution).

Food

As a Food Additive, it is used as an acidity regulator and can be denoted by the E number E297. It is generally used in beverages and baking powders for which requirements are placed on purity. Fumaric acid is used in the making of wheat tortillas as a food preservative and as the acid in leavening. It is generally used as a substitute for Tartaric acid and occasionally in place of Citric acid, at a rate of 1 g of fumaric acid to every ~1.5 g of citric acid, in order to add sourness, similarly to the way Malic acid is used. As well as being a component of some artificial vinegar flavors, such as "Salt and Vinegar" flavored potato chips it is also used as a coagulant in stove-top pudding mixes.

Medicine

In patients with relapsing-remitting multiple sclerosis, the ester dimethyl fumarate (BG-12, Biogen) significantly reduced relapse and disability progression in a phase 3 trial. It activates the Nrf2 antioxidant response pathway, the primary cellular defense against the cytotoxic effects of oxidative stress.

Psoriasis

Various fumaric acid esters (FAES) have specific immunomodulating (respectively moderate immunosuppression) properties which are responsible for certain effects in the treatment of psoriasis. 

 Although it seems that a certain effectiveness exists (and many studies have confirmed the effect), more statistically powerful studies are necessary to provide better evidence of the effectiveness of fumaric acid esters in treatment of psoriasis (e.g. more accurate in terms of the dermatological nosology of this autoimmune disease). Such studies should in the future help specify which psoriasis variants (in terms of the course, the immunological profile of the patient etc.) are suited to be treated with fumaric acid esters.

Fumaric acid is naturally present in the herb called Fumaria officinalis. The top of this herb is used to treat various skin disorders including psoriasis. Baths with this herb have been used for several centuries. At present, these baths (after consultation with a general practitioner or dermatologist) are used as an adjunct therapy to basic treatment.

Other uses

Fumaric acid is used in the manufacture of polyester resins and polyhydric alcohols and as a mordant for dyes. Since the early 21st century, it has been used to synthesize one of the first metal-organic frameworks presenting commercial applications thanks to its remarkable adsorption and mechanical properties, combined with a low toxicity compared to other well-studied MOFs.

FAQ

1. What's your payment terms?

T/T, D/P, L/C, O/A

2. What's your delivery time?

Usually we will arrange the shipment within 14 days.

3. How about the packing?

Usually with 25 kg bag/carton/drum.

4. How about the validity of the products?

Usually 2 or 3 years.

5. What documents you provide?

Usually, Commerical Invoice, Packing List, Country of Origin, Insurance Policy, Bill of loading, COA , Health certificate.

6. What is loading port?

Usually, Qingdao, Tianjin and Shanghai